Until

Today we’re publishing Glass, Not Ice. It’s a detailed walkthrough of what a reversible cryopreservation protocol could look like, and why we're building this technology first for patients who need an organ transplant. Check it out here 👉 https://lnkd.in/gswTb3yW

We partnered with the exceptional team at basement.studio to create a new brand and website for Until. We’re so excited to finally share what we’ve been working on: ✨ https://www.untillabs.com/ ✨ For our homepage, we hoped show that reversible cryopreservation is, at its core, a molecular physics problem. basement.studio nailed this 💪 You can zoom into the molecular landscape of a person, observe the scene as the temperature gets cooler and motion slows to a complete halt. Ice is the enemy. Everything we engineer is in service of preventing it. And lastly, the whole point of this endeavor, is to have more time with our loved ones, more peaceful afternoons, more picnics in the sun, more precious moments. We're building for people we love. We also wanted our new site to highlight the people making reversible cryopreservation real. Our team is full of rockstar scientists and engineers and operational magicians. Their commitment, their late-night sprints, their creative investment, and rigor are what moves this technology forward. To our team, thank you ❤️ They are working at one of the most ambitious intersections of biology, physics, and hardware. If that sounds like your kind of challenge, we’re hiring. https://lnkd.in/gzi8Jav3 We couldn't have asked for a better collaborator than basement.studio. They developed a brand that feels warm, captures our soul, and celebrates our incredible team, Thank you so much! :) <3 

We recently partnered with the remarkable folks at Card79 to create visual walk-through of what reversibly cryopreserving a kidney might look like. What you’re watching: A donated kidney is perfused with cryoprotectants, replacing the water in its cells, and nanoparticles, for later rewarming. The organ is cooled below –130°C, pausing molecular motion, the organ can safely stay at this temperature indefinitely, until the right recipient is ready. This rendition of time passing as the organ stays safely preserved in the a biobank is our favorite scene ❤️ When a perfect match is found, the organ is gently rewarmed in an alternating magnetic field coil, cryoprotectants and nanoparticles are flushed out, blood is re-perfused, health and vitals are assessed, and the organ is ready for transplant, set to save a life. Until’s mission is simple: Pause molecular motion to give patients more time. We aim to extend viable preservation from hours to weeks — until matching, transport, and transplant are no longer a race against the clock. Card79 went above and beyond. Thank you for bringing rigor, care, and beauty to this collaboration. You took an incredibly complex process and created a visual distillation that is intuitive and clear 👏

Looking for exceptional mechanical engineers full of taste to help spearhead next-gen systems design at Until. If you join our team and are successful you'll make something that will touch the lives of hundreds of millions of patients. If you or someone you know loves to make beautiful physical products and would rather use those abilities to drive progress in human health than make widgets for a car or TV, please DM or email john@untillabs.com with the thing you're most proud of making. JDs in the comment section below. Looking for FT, ideal start date yesterday.

I’m constantly amazed by what the team at Until is building🧬 — pushing the limits of science to make sure that when time runs out, we have more ways to save it. On November 4th, our team will be in NY to talk about how cryopreservation is shaping the future of medicine — and what’s possible when brilliant minds come together across disciplines to solve problems that truly matter. If this kind of work speaks to you, come be part of the conversation! 🔗 RSVP here: https://luma.com/vvcnnqyt

Until is coming to New York! Come hear about our progress and chat with members of our team on Nov 4th 🌆

Check out our CEO Laura Deming's conversation with Mario Gabriele on The Generalist Podcast! Their discussion traverses many things: the legitimization of stigmatized research areas in health, why she founded Until, our approach to building reversible cryopreservation tech for donor organs, meeting our CSO and co-founder Hunter Davis, embracing weirdness, and much more 🙂 It is a deep and nuanced dive. Thank you Mario for such thoughtful questions and explorations 💕

We’ve raised $100M+ to date, we are developing reversible cryopreservation for patients in need of donor organs, and we are hiring 🫀🎉🚀 We’ve closed a $58M Series A, led by Founders Fund with Lux Capital and Field Ventures joining, to support development of an organ cryopreservation product. In the near term, this will help transplant patients and surgeons access the organs they need. This also serves as an important step in our long-term roadmap to medical hibernation. The timing of an organ donation is critical. Most organs remain viable for only hours after procurement, 4–12 for hearts, lungs, and livers; 24–36 for kidneys. That narrow window means patients live tethered to hospitals, and thousands of organs are lost every year due to logistics.  We’re changing that. We’re building reversible cryopreservation so that every donated organ with the potential to save a life, can. We’re building the whole stack: • novel cryoprotectants • custom cooling & rewarming hardware • perfusion & surgical protocols • molecular modeling engines • magnetic rewarming systems We started in neural slices. Now we’re preserving preclinical model organs. This work lays the foundations for our long term vision of whole-body medical hibernation technology. You can read our updated Problem Statement and Roadmap here: https://lnkd.in/gV9cqiUS 👀 Over the last year, we’ve built a CPA discovery engine, designed a custom electromagnet, and iterated cooling protocols to reduce time-to-glass. We’re now testing in large animal organs — optimizing for quality post cryopreservation. Our lab traverses disciplines, a single day at Until might span simulating molecular dynamics, running benchtop assays with high throughput liquid-handling robots, mapping vasculature, exploring the physics of high voltage electromagnets, or designing topologically optimized heat exchangers. Our perfusion experts and molecular biologists work in close collaboration with our hardware engineers and physicists. The team is diverse by design because the problem is diverse by nature. We move between theory and practice, from first principles to functional prototypes. If you’re energized by deep technical problems, mission-driven science, and rendering technology to extend human well-being, join us. And of course, the fundraise would not have been possible without our incredible team, thank you ❤️

We’re hiring Histologists, Research Associates, and Scientists for our Organ Perfusion team at Until. Help us scale reversible cryopreservation and build technology to pause biological time, so that no donated organ is lost to time. Apply here: https://lnkd.in/g4Vw-3me